Tumour break load is a biologically relevant feature of genomic instability with prognostic value in colorectal cancer
We are pleased to share our recent publication by Soufyan Lakbir and Sanne Abeln in collaboration with Remond Fijneman, showing that the Tumor Break Load (TBL) is a distinct feature of genomic instability with prognostic value for patients with resected stage II and III microsatellite stable colorectal cancer. Highlights Abstract Background Clinically implemented prognostic biomarkers are lacking for the 80% of colorectal cancers (CRCs) that exhibit chromosomal instability (CIN). CIN is characterised by chromosome segregation errors and double-strand break repair defects that lead to…